Tigit - SNV Details



 Gene Information 
Gene Name Tigit
Old Gene Names for Tigit Ensmusg00000071552 , Vstm3
Gene Description T cell immunoreceptor with Ig and ITIM domains [Source:MGI Symbol;Acc:MGI:3642260]
Uniprot Name
CCDS Name
Gene GO
negative regulation of T cell activation; protein binding; cell surface; receptor binding; negative regulation of interleukin-12 production; positive regulation of interleukin-10 production
Homolog in other species TIGIT
Omim http://omim.org/entry/612859
Immgen Expression
MEDIAN(HIGH IN TGD GROUP, NK GROUP, T.8EFF.SP.OT1.D6.VSVOVA, T.4MEM.SP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000071552
Chromosome 16
Coordinate 43,659,522     (Assembly: GRCm38)    
Ref Base T
Codon Change Act/Gct
Var Base C
Zygosity Heterozygous
Read Depth 35
Allele Frequency
T:R0.43
C:V0.57
Amino Acid Position 137
Amino Acid Change T->A (Threonine -> Alanine)
Sample ID IGL01479
Median Base Quality 37
Backgrounds Balb/c:C57BL/6
Source Walter and Eliza Hall Institute (WEHI-G1)
Other variants in this mouse 29 Other Mutations

 Predictions 
Sift Score 0.68
Sift Prediction tolerated

 Availability Details 
Availability Cryopreserved