Tle4 - SNV Details



 Gene Information 
Gene Name Tle4
Old Gene Names for Tle4 X83333 , 5730411m05rik , Aa792082 , Estm13 , Estm14 , X83332
Gene Description transducin-like enhancer of split 4, homolog of Drosophila E(spl) [Source:MGI Symbol;Acc:MGI:104633]
Uniprot Name
CCDS Name
Gene GO
negative regulation of transcription
DNA-dependent; Wnt receptor signaling pathway; chromatin binding; transcription corepressor activity; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; repressing transcription factor binding
Homolog in other species TLE4
Immgen Expression
MEDIAN(LOWER IN MYELOID GROUP AND DC.LC.SK)
Gnf Expression
LOW/MEDIAN
HIGH(LOWER IN FERTILIZEDEGG, PANCREAS, BROWNFAT, THYROID)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000024642
Chromosome 19
Coordinate 14,465,340     (Assembly: GRCm38)    
Ref Base A
Codon Change Tct/Cct
Var Base G
Zygosity Heterozygous
Read Depth 81
Allele Frequency
A:R0.57
G:V0.43
Amino Acid Position 339
Amino Acid Change S->P (Serine -> Proline)
Sample ID IGL01449
Median Base Quality 38
Backgrounds Balb/c:C57BL/6
Source Walter and Eliza Hall Institute (WEHI-G1)
Other variants in this mouse 42 Other Mutations

 Predictions 
Polyphen Score 0
Polyphen Prediction Benign
Sift Score 0.05
Sift Prediction deleterious

 Availability Details 
Availability Cryopreserved