Gls2 - SNV Details



 Gene Information 
Gene Name Gls2
Old Gene Names for Gls2 A330074b06rik , Ai195532
Gene Description glutaminase 2 (liver, mitochondrial) [Source:MGI Symbol;Acc:MGI:2143539]
Uniprot Name
CCDS Name
Gene GO
mitochondrion; glutamine metabolic process; protein binding; reactive oxygen species metabolic process; glutaminase activity; regulation of apoptotic process; molecular_function
Homolog in other species GLS2
Omim http://omim.org/entry/606365
Immgen Expression
MEDIAN(HIGHER IN DC.LC.SK)
Gnf Expression
LOW/MEDIAN(HIGH IN KIDNEY, LIVER, SMALLINTESTINE)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000044005
Chromosome 10
Coordinate 128,201,347     (Assembly: GRCm38)    
Ref Base C
Codon Change aaC/aaA
Var Base A
Zygosity Heterozygous
Read Depth 33
Allele Frequency
C:R0.45
A:V0.55
Amino Acid Position 252
Amino Acid Change N->K (Asparagine -> Lysine)
Sample ID IGL01444
Median Base Quality 37
Backgrounds Balb/c:C57BL/6
Source Walter and Eliza Hall Institute (WEHI-G1)
Other variants in this mouse 39 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000047376:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Glutaminase Glutaminase IPR015868 ENSMUSP00000047376 TIGRfam 171
457 Description available Search pathways
Glutaminase Glutaminase IPR015868 ENSMUSP00000047376 Pfam 177
463 Description available Search pathways
Beta-lactamase/transpeptidase-like Beta-lactam/transpept-like IPR012338 ENSMUSP00000047376 Superfamily 163
463 Description available Search pathways

 Availability Details 
Availability Cryopreserved