Gls2 - SNV Details



 Gene Information 
Gene Name Gls2
Old Gene Names for Gls2 A330074b06rik , Ai195532
Gene Description glutaminase 2 (liver, mitochondrial) [Source:MGI Symbol;Acc:MGI:2143539]
Uniprot Name
CCDS Name
Gene GO
mitochondrion; glutamine metabolic process; protein binding; reactive oxygen species metabolic process; glutaminase activity; regulation of apoptotic process; molecular_function
Homolog in other species GLS2
Omim http://omim.org/entry/606365
Immgen Expression
MEDIAN(HIGHER IN DC.LC.SK)
Gnf Expression
LOW/MEDIAN(HIGH IN KIDNEY, LIVER, SMALLINTESTINE)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000044005
Chromosome 10
Coordinate 128,201,347     (Assembly: GRCm38)    
Ref Base C
Codon Change aaC/aaA
Var Base A
Zygosity Heterozygous
Read Depth 33
Allele Frequency
C:R0.45
A:V0.55
Amino Acid Position 252
Amino Acid Change N->K (Asparagine -> Lysine)
Sample ID IGL01444
Median Base Quality 37
Backgrounds Balb/c:C57BL/6
Source Walter and Eliza Hall Institute (WEHI-G1)
Other variants in this mouse 39 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000047376:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Glutaminase Glutaminase IPR015868 ENSMUSP00000047376 TIGRfam 171
457 Description available Search pathways
Beta-lactamase/transpeptidase-like Beta-lactam/transpept-like IPR012338 ENSMUSP00000047376 Superfamily 163
463 Description available Search pathways
Glutaminase Glutaminase IPR015868 ENSMUSP00000047376 Pfam 177
463 Description available Search pathways

 Availability Details 
Availability Cryopreserved