Lats1 - SNV Details

 Gene Information 
Gene Name Lats1
Old Gene Names for Lats1 Aw208599
Gene Description large tumor suppressor [Source:MGI Symbol;Acc:MGI:1333883]
MGI phenotype Homozygotes for a targeted null mutation exhibit high postnatal mortality, lack of mammary development, infertility, pituitary hyperplasia, reduced hormone levels, growth retardation, and susceptibility to sarcomas and ovarian stromal cell tumors.
Uniprot Name
Gene GO
cell division; protein kinase activity; sister chromatid segregation; regulation of actin filament polymerization; mitosis; keratinocyte differentiation; positive regulation of peptidyl-serine phosphorylation; negative regulation of canonical Wnt receptor signaling pathway; transferase activity
transferring phosphorus-containing groups; negative regulation of cyclin-dependent protein kinase activity; protein binding; hormone-mediated signaling pathway; magnesium ion binding; hippo signaling cascade; microtubule organizing center; protein phosphorylation; G2/M transition of mitotic cell cycle; spindle pole; protein tyrosine kinase activity; regulation of protein complex assembly; ATP binding; cellular protein localization; protein kinase binding; protein serine/threonine kinase activity; cytoplasmic sequestering of protein
Homolog in other species LATS1
Immgen Expression
Gnf Expression
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000040021
Chromosome 10
Coordinate 7,691,780     (Assembly: GRCm38)    
Ref Base T
Codon Change aTg/aAg
Var Base A
Zygosity Heterozygous
Read Depth 72
Allele Frequency
Amino Acid Position 105
Amino Acid Change M->K (Methionine -> Lysine)
Sample ID IGL01380
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 62 Other Mutations

Polyphen Score 0.63
Polyphen Prediction Possibly damaging
Sift Score 0.06
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved , Cryopreserved