Cdk14 - SNV Details



 Gene Information 
Gene Name Cdk14
Old Gene Names for Cdk14 Pftk1
Gene Description cyclin-dependent kinase 14 [Source:MGI Symbol;Acc:MGI:894318]
Uniprot Name
CCDS Name
Gene GO
Wnt receptor signaling pathway; cell division; protein kinase activity; cytoplasm; cyclin-dependent protein kinase activity; transferase activity
transferring phosphorus-containing groups; protein binding; nucleus; regulation of canonical Wnt receptor signaling pathway; cytosol; protein phosphorylation; G2/M transition of mitotic cell cycle; protein tyrosine kinase activity; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; ATP binding; plasma membrane; protein serine/threonine kinase activity; cyclin binding
Homolog in other species CDK14
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000028926
Chromosome 5
Coordinate 5,010,839     (Assembly: GRCm38)    
Ref Base T
Codon Change atA/atG
Var Base C
Zygosity Heterozygous
Read Depth 62
Allele Frequency
T:R0.40
C:V0.60
Amino Acid Position 345
Amino Acid Change I->M (Isoleucine -> Methionine)
Sample ID IGL01376
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 35 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000030763:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Protein kinase domain Prot_kinase_cat_dom IPR000719 ENSMUSP00000030763 Pfam 135
419 Description available Search pathways
Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom IPR020635 ENSMUSP00000030763 Smart 135
419 Description available Search pathways
Serine/threonine- / dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom IPR002290 ENSMUSP00000030763 Smart 135
419 Description available Search pathways
Protein kinase domain Prot_kinase_cat_dom IPR000719 ENSMUSP00000030763 Prosite_profiles 135
419 Description available Search pathways
Protein kinase-like domain Kinase-like_dom IPR011009 ENSMUSP00000030763 Superfamily 121
450 Description available Search pathways

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved