Oc90 - SNV Details



 Gene Information 
Gene Name Oc90
Old Gene Names for Oc90 Pla2ll
Gene Description otoconin 90 [Source:MGI Symbol;Acc:MGI:1313269]
MGI phenotype Mice homozygous for a null allele exhibit reduced, enlarged, and loose otoliths, and thin cupula, saccule, utricle and tectorial membranes.
Uniprot Name
CCDS Name
Gene GO
phospholipase A2 activity; proteinaceous extracellular matrix; structural molecule activity; lipid catabolic process; calcium ion binding; phospholipid metabolic process
Homolog in other species OC90
Omim http://omim.org/entry/601658
Immgen Expression
MEDIAN
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000015001
Chromosome 15
Coordinate 65,889,591     (Assembly: GRCm38)    
Ref Base T
Codon Change Act/Gct
Var Base C
Zygosity Heterozygous
Read Depth 26
Allele Frequency
T:R0.42
C:V0.58
Amino Acid Position 193
Amino Acid Change T->A (Threonine -> Alanine)
Sample ID IGL01343
Median Base Quality 36
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 57 Other Mutations

 Predictions 
Polyphen Score 0.01
Polyphen Prediction Benign
Sift Score 0.29
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000062865:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Phospholipase A2 domain PLipase_A2_dom IPR016090 ENSMUSP00000062865 Superfamily 74
197 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved