Trim63 - SNV Details



 Gene Information 
Gene Name Trim63
Old Gene Names for Trim63 Rnf28
Gene Description tripartite motif-containing 63 [Source:MGI Symbol;Acc:MGI:2447992]
MGI phenotype A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
Uniprot Name
CCDS Name
Gene GO
proteasomal ubiquitin-dependent protein catabolic process; muscle contraction; intracellular; zinc ion binding; ubiquitin-protein ligase activity; response to glucocorticoid stimulus; protein binding; protein ubiquitination; titin binding; contractile fiber; response to interleukin-1; skeletal muscle atrophy
Homolog in other species TRIM63
Immgen Expression
MEDIAN
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000028834
Chromosome 4
Coordinate 134,325,676     (Assembly: GRCm38)    
Ref Base C
Codon Change gCa/gTa
Var Base T
Zygosity Heterozygous
Read Depth 38
Allele Frequency
C:R0.61
T:V0.40
Amino Acid Position 316
Amino Acid Change A->V (Alanine -> Valine)
Sample ID IGL01152
Median Base Quality 38.5
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 56 Other Mutations

 Predictions 
Sift Score 0.1
Sift Prediction tolerated

 Availability Details 
Availability Progeny Cryopreserved