Clk1 - SNV Details



 Gene Information 
Gene Name Clk1
Gene Description CDC-like kinase 1 [Source:MGI Symbol;Acc:MGI:107403]
Uniprot Name
CCDS Name
Gene GO
protein kinase activity; protein autophosphorylation; cytoplasm; regulation of RNA splicing; peptidyl-tyrosine phosphorylation; transferase activity
transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; nucleus; protein phosphorylation; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity
Homolog in other species CLK1
Omim http://omim.org/entry/601683
Immgen Expression
HIGH
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000026034
Chromosome 1
Coordinate 58,413,452     (Assembly: GRCm38)    
Ref Base A
Codon Change Tgt/Agt
Var Base T
Zygosity Heterozygous
Read Depth 41
Allele Frequency
A:R0.32
T:V0.68
Amino Acid Position 359
Amino Acid Change C->S (Cysteine -> Serine)
Sample ID IGL01152
Median Base Quality 39
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 56 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0.01
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000034868:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom IPR001245 ENSMUSP00000034868 Pfam 162
390 Description available Search pathways
Serine/threonine- / dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom IPR002290 ENSMUSP00000034868 Smart 160
476 Description available Search pathways
Protein kinase domain Prot_kinase_cat_dom IPR000719 ENSMUSP00000034868 Prosite_profiles 160
476 Description available Search pathways
Protein kinase domain Prot_kinase_cat_dom IPR000719 ENSMUSP00000034868 Pfam 160
476 Description available Search pathways
Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom IPR020635 ENSMUSP00000034868 Smart 160
476 Description available Search pathways
Protein kinase-like domain Kinase-like_dom IPR011009 ENSMUSP00000034868 Superfamily 146
477 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved