Abcc10 - SNV Details

 Gene Information 
Gene Name Abcc10
Gene Description ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [Source:MGI Symbol;Acc:MGI:2386976]
MGI phenotype Mice homzozygous for a knock-out allele exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells.
Uniprot Name
Gene GO
ATPase activity; integral to membrane; nucleoside-triphosphatase activity; transport; nucleotide binding; ATPase activity
coupled to transmembrane movement of substances; transmembrane transport; ATP binding; plasma membrane
Homolog in other species ABCC10
Immgen Expression
Gnf Expression
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000032842
Chromosome 17
Coordinate 46,310,426     (Assembly: GRCm38)    
Ref Base T
Codon Change Aca/Gca
Var Base C
Zygosity Heterozygous
Read Depth 20
Allele Frequency
Amino Acid Position 934
Amino Acid Change T->A (Threonine -> Alanine)
Sample ID IGL01115
Median Base Quality 36
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 35 Other Mutations

Polyphen Score 0
Polyphen Prediction Benign
Sift Score 0.77
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Protein domains 
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
ABC_transporter_type1 IPR017940 ENSMUSP00000131843 Prosite_profiles 888
ABC transporter type 1, transmembrane domain ABC_transptrTM_dom_typ1 IPR011527 ENSMUSP00000131843 Superfamily 875
1231 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved , Cryopreserved