Gas6 - SNV Details



 Gene Information 
Gene Name Gas6
Old Gene Names for Gas6 Gas-6
Gene Description growth arrest specific 6 [Source:MGI Symbol;Acc:MGI:95660]
MGI phenotype Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed.
Uniprot Name
CCDS Name
Gene GO
dendritic cell differentiation; negative regulation of oligodendrocyte apoptotic process; negative regulation of transcription
DNA-dependent; negative regulation of interleukin-6 secretion; positive regulation of fibroblast proliferation; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cellular response to drug; protein kinase B signaling cascade; positive regulation of protein tyrosine kinase activity; negative regulation of tumor necrosis factor-mediated signaling pathway; viral entry into host cell; protein tyrosine kinase activator activity; cellular response to interferon-alpha; positive regulation of protein kinase B signaling cascade; cytoplasm; signal transduction; positive regulation of protein phosphorylation; negative regulation of apoptotic process; negative regulation of interferon-gamma production; positive regulation of TOR signaling cascade; negative regulation of interleukin-1 secretion; negative regulation of fibroblast apoptotic process; intracellular; positive regulation of peptidyl-serine phosphorylation; negative regulation of endothelial cell apoptotic process; apoptotic cell clearance; viral genome replication; blood coagulation; negative regulation of sequence-specific DNA binding transcription factor activity; cellular response to starvation; binding
bridging; positive regulation of glomerular filtration; protein binding; hematopoietic stem cell migration to bone marrow; peptidyl-serine phosphorylation; negative regulation of renal albumin absorption; positive regulation of ERK1 and ERK2 cascade; neuron migration; enzyme linked receptor protein signaling pathway; regulation of growth; virion attachment
binding of host cell surface receptor; protein targeting to plasma membrane; phosphatidylserine binding; negative regulation of dendritic cell apoptotic process; negative regulation of interleukin-6 production; receptor tyrosine kinase binding; macrophage cytokine production; cellular response to growth factor stimulus; protein phosphorylation; positive regulation of protein kinase activity; activation of protein kinase B activity; extracellular region; voltage-gated calcium channel activity; phagocytosis; positive regulation of protein export from nucleus; cellular response to glucose stimulus; extracellular matrix assembly; positive regulation of dendritic cell chemotaxis; receptor binding; cell-substrate adhesion; negative regulation of tumor necrosis factor production; cellular response to vitamin K; organ regeneration; B cell chemotaxis; positive regulation of natural killer cell differentiation; calcium ion binding; viral entry into host cell via membrane fusion with the plasma membrane; negative regulation of biomineral tissue development; extracellular space; positive regulation of phagocytosis; positive regulation of cytokine-mediated signaling pathway; negative regulation of protein import into nucleus
translocation; positive regulation of gene expression; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; receptor agonist activity
Homolog in other species GAS6
Omim http://omim.org/entry/600441
Immgen Expression
LOW/MEDIAN(HIGH IN MF.THIO5.II-480HI.PC)
Gnf Expression
HIGH(LOWER IN TESTIS, FERTILIZEDEGG, OOCYTE, LIVER, EMB GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000031451
Chromosome 8
Coordinate 13,475,118     (Assembly: GRCm38)    
Ref Base C
Codon Change Gtg/Atg
Var Base T
Zygosity Heterozygous
Read Depth 19
Allele Frequency
C:R0.53
T:V0.47
Amino Acid Position 289
Amino Acid Change V->M (Valine -> Methionine)
Sample ID IGL01100
Median Base Quality 35
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 32 Other Mutations

 Predictions 
Polyphen Score 0
Polyphen Prediction Benign
Sift Score 0.22
Sift Prediction tolerated

 Availability Details 
Availability Progeny Cryopreserved