Ndst3 - SNV Details

 Gene Information 
Gene Name Ndst3
Old Gene Names for Ndst3 4921531k01rik , 4930511p15rik
Gene Description N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 [Source:MGI Symbol;Acc:MGI:1932544]
MGI phenotype Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation.
Uniprot Name
Gene GO
Golgi membrane; integral to membrane; hydrolase activity; deacetylase activity; heparin biosynthetic process; [heparan sulfate]-glucosamine N-sulfotransferase activity; heparan sulfate proteoglycan biosynthetic process; sulfotransferase activity
Homolog in other species NDST3
Immgen Expression
Gnf Expression
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000027977
Chromosome 3
Coordinate 123,546,817     (Assembly: GRCm38)    
Ref Base T
Codon Change cAg/cGg
Var Base C
Zygosity Heterozygous
Read Depth 58
Allele Frequency
Amino Acid Position 784
Amino Acid Change Q->R (Glutamine -> Arginine)
Sample ID IGL01067
Median Base Quality 39
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 51 Other Mutations

Polyphen Score 0.92
Polyphen Prediction Possibly damaging
Sift Score 0.01
Sift Prediction deleterious

 Availability Details 
Availability Progeny Cryopreserved , Cryopreserved