Msra - SNV Details



 Gene Information 
Gene Name Msra
Old Gene Names for Msra 2310045j23rik , 6530413p12rik
Gene Description methionine sulfoxide reductase A [Source:MGI Symbol;Acc:MGI:106916]
MGI phenotype Mice homozygous for disruptions in this allele display an increased sensitivity to oxidative stress, reductions in related enzyme levels, and reduced life spans.
Uniprot Name
CCDS Name
Gene GO
acting on a sulfur group of donors
disulfide as acceptor
aging
cytoplasm
mitochondrion
oxidation-reduction process
oxidoreductase activity
peptide-methionine-(S)-S-oxide reductase activity
protein metabolic process
protein modification process
Homolog in other species MSRA
Immgen Expression
MEDIAN(HIGHER IN MYELOID GROUP, TGD.VG5+.ACT.IEL)
Gnf Expression
LOW/MEDIAN(HIGH IN KIDNEY, LIVER, BLASTOCYSTS, GI GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000054733
Chromosome 14
Coordinate 64,123,325     (Assembly: GRCm38)    
Ref Base A
Codon Change aTc/aCc
Var Base G
Zygosity Heterozygous
Read Depth 11
Allele Frequency
A:0.45
G:0.55
Amino Acid Position 189
Amino Acid Change I->T (Isoleucine -> Threonine)
Sample ID IGL00898
Median Base Quality 38
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 41 Other Mutations

 Predictions 
Polyphen Score 0.87
Polyphen Prediction Possibly damaging
Sift Score 0.01
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000065754:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Peptide methionine sulphoxide reductase MsrA Met_Sox_Rdtase_MsrA IPR002569 ENSMUSP00000065754 Pfam 65
218 Description available Search pathways
Peptide methionine sulphoxide reductase MsrA Met_Sox_Rdtase_MsrA IPR002569 ENSMUSP00000065754 TIGRfam 65
218 Description available Search pathways
Peptide methionine sulphoxide reductase MsrA Met_Sox_Rdtase_MsrA IPR002569 ENSMUSP00000065754 Superfamily 21
231 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved