Agtr1b - SNV Details



 Gene Information 
Gene Name Agtr1b
Old Gene Names for Agtr1b Agtr-1b , Angtr-1b
Gene Description angiotensin II receptor, type 1b [Source:MGI Symbol;Acc:MGI:87965]
MGI phenotype Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout.
Uniprot Name
CCDS Name
Gene GO
blood vessel development; vesicle lumen; phospholipase C-activating angiotensin-activated signaling pathway; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; response to estrogen; response to hypoxia; positive regulation of cytosolic calcium ion concentration; integral component of membrane; inflammatory response; kidney development; protein self-association; peptide hormone binding; angiotensin type II receptor activity; cellular response to dexamethasone stimulus; drinking behavior; response to drug; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; positive regulation of branching involved in ureteric bud morphogenesis; basolateral plasma membrane; angiotensin type I receptor activity; vesicle membrane; regulation of vasoconstriction; response to nutrient; response to immobilization stress
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.DPSM.TH, T.8EFF.SP.OT1.D6.VSVOVA, T.8MEM.LN,TGD.SP,T.4FP3+25+.SP,T.4NVE.PP)
Gnf Expression
MEDIAN(HIGH IN ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000054988
Chromosome 3
Coordinate 20,315,795     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 39
Allele Frequency
T:R0.56
C:V0.44
Amino Acid Change T->A (Threonine -> Alanine)
Sample ID IGL03243
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 32 Other Mutations

 Predictions 
Polyphen Score 0.31
Polyphen Prediction Benign
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved