Lyl1 - SNV Details



 Gene Information 
Gene Name Lyl1
Old Gene Names for Lyl1 Lyl-1
Gene Description lymphoblastomic leukemia 1 [Source:MGI Symbol;Acc:MGI:96891]
MGI phenotype Mice with mutation of this gene are vaible and fertile. Defects in production and differentiation of progenitor cells are observed, along with impaired ability of fetal liver or bone marrow cells in reconstituting B and T lineages after transplant.
Uniprot Name
CCDS Name
Gene GO
positive regulation of transcription
DNA-templated; regulation of transcription
DNA-templated; blood vessel maturation; B cell differentiation; DNA binding; protein binding; nucleus; protein dimerization activity; transcription
DNA-templated; definitive hemopoiesis
Homolog in other species LYL1
Omim http://omim.org/entry/151440
Immgen Expression
MEDIAN(HIGHER IN BCELL GROUP)
Gnf Expression
MEDIAN
LOW/MEDIAN(HIGH IN IMM.G1, IMM.G2, SPLEEN, TRACHEA, ADIPOSETISSUE)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000034041
Chromosome 8
Coordinate 84,702,671     (Assembly: GRCm38)    
Ref Base C
Var Base T
Zygosity Heterozygous
Read Depth 34
Allele Frequency
C:R0.56
T:V0.44
Amino Acid Change P->L (Proline -> Leucine)
Sample ID IGL03146
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 43 Other Mutations

 Predictions 
Polyphen Score 0.05
Polyphen Prediction Benign

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved