Polr1b - SNV Details



 Gene Information 
Gene Name Polr1b
Old Gene Names for Polr1b D630020h17rik , Rpo1-2
Gene Description polymerase (RNA) I polypeptide B [Source:MGI Symbol;Acc:MGI:108014]
MGI phenotype Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.
Uniprot Name
CCDS Name
Gene GO
nucleoplasm; nucleologenesis; cytoplasm; metal ion binding; DNA binding; protein binding; DNA-directed RNA polymerase I complex; transcription from RNA polymerase I promoter; nucleus; ribonucleoside binding; rRNA transcription; RNA polymerase I activity; embryo implantation; DNA-directed RNA polymerase activity; nucleolus; transcription
DNA-templated
Homolog in other species POLR1B
Immgen Expression
MEDIAN(LOW IN GN.BM, HIGH IN B.GC.SP, PROB.FRBC.FL)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000027395
Chromosome 2
Coordinate 129,115,707     (Assembly: GRCm38)    
Ref Base G
Var Base A
Zygosity Heterozygous
Read Depth 30
Allele Frequency
G:R0.57
A:V0.43
Amino Acid Change V->I (Valine -> Isoleucine)
Sample ID IGL03129
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 28 Other Mutations

 Predictions 
Polyphen Score 0
Polyphen Prediction Benign

 Availability Details 
Availability Progeny Cryopreserved , Line Propagating