Trib1 - SNV Details



 Gene Information 
Gene Name Trib1
Gene Description tribbles homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:2443397]
MGI phenotype Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA.
Uniprot Name
CCDS Name
Gene GO
negative regulation of smooth muscle cell proliferation; response to lipopolysaccharide; positive regulation of ubiquitin-protein transferase activity; protein kinase activity; mitogen-activated protein kinase kinase binding; cytoplasm; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin protein ligase binding; transferase activity
transferring phosphorus-containing groups; negative regulation of smooth muscle cell migration; ubiquitin-protein transferase regulator activity; negative regulation of protein kinase activity; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; JNK cascade; protein kinase inhibitor activity; protein phosphorylation; ATP binding; transcription factor binding; regulation of MAP kinase activity; negative regulation of lipopolysaccharide-mediated signaling pathway
Homolog in other species TRIB1
Omim http://omim.org/entry/609461
Immgen Expression
MEDIAN(HIGH IN DC GROUP)
Gnf Expression
LOW
MEDIAN
LOW/MEDIAN(HIGH IN IMM GROUP, OSTEO GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000032501
Chromosome 15
Coordinate 59,654,484     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 71
Allele Frequency
T:R0.49
C:V0.51
Amino Acid Change F->S (Phenylalanine -> Serine)
Sample ID IGL03018
Median Base Quality 36
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 34 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging

 Availability Details 
Availability Cryopreserved