Hrh3 - SNV Details



 Gene Information 
Gene Name Hrh3
Old Gene Names for Hrh3 Aw049250
Gene Description histamine receptor H3 [Source:MGI Symbol;Acc:MGI:2139279]
MGI phenotype Homozygotes for a targeted null mutation exhibit reduced locomotor activity and body temperature, and attenuated behavioral responses to the drugs thioperamide, methamphetamine, and scopolamine.
Uniprot Name
CCDS Name
Gene GO
negative regulation of glutamate secretion; positive regulation of epithelial cell proliferation; drug binding; negative regulation of gamma-aminobutyric acid secretion; regulation of norepinephrine secretion; negative regulation of serotonin secretion; negative regulation of blood pressure; negative regulation of adenylate cyclase activity; regulation of neurotransmitter levels; positive regulation of cytosolic calcium ion concentration; cognition; integral component of membrane; response to organic cyclic compound; drinking behavior; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; neuron projection; plasma membrane; histamine receptor activity; eating behavior; memory; learning; myelin sheath; brain development
Homolog in other species HRH3
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.DPSM.TH, T.8EFF.SP.OT1.D6.VSVOVA, T.8MEM.LN,TGD.SP,T.4FP3+25+.SP,T.4NVE.PP)
Gnf Expression
HIGH(HIGHER IN IMM GROUP, NS GROUPS)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000039059
Chromosome 2
Coordinate 180,100,815     (Assembly: GRCm38)    
Ref Base A
Var Base G
Zygosity Heterozygous
Read Depth 23
Allele Frequency
A:R0.43
G:V0.56
Amino Acid Change V->A (Valine -> Alanine)
Sample ID IGL02992
Median Base Quality 36
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 48 Other Mutations

 Predictions 
Polyphen Score 0.48
Polyphen Prediction Possibly damaging

 Availability Details 
Availability Progeny Cryopreserved