Mcm3 - SNV Details



 Gene Information 
Gene Name Mcm3
Old Gene Names for Mcm3 Al033361 , C80350 , Mcmd
Gene Description minichromosome maintenance deficient 3 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:101845]
MGI phenotype Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
Uniprot Name
CCDS Name
Gene GO
perinuclear region of cytoplasm; membrane; chlorophyll biosynthetic process; cytoplasm; cell cycle; DNA replication; MCM complex; DNA binding; DNA helicase activity; intracellular membrane-bounded organelle; nucleoside-triphosphatase activity; protein binding; nucleus; DNA duplex unwinding; magnesium chelatase activity; DNA replication initiation; nucleotide binding; photosynthesis; ATP binding; centrosome
Homolog in other species MCM3
Omim http://omim.org/entry/602693
Immgen Expression
MEDIAN(HIGH IN B.GC.SP, PROB.FRBC.FL, PREB.FRD.FL, DC8+.TH, TGD.VG5+.ACT.IEL, NK.MCMV1.SP, T.8EFF.SP.OT1.D6.VSVOVA, TGD.TH, T.4SP24-.TH, T.8SP24-.TH, DC.LC.SK)
Gnf Expression
MEDIAN(HIGH IN TESTIS, FERTILIZEDEGG, OOCYTE, IMM GROUP, OSTEO GROUP, EMB GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000041859
Chromosome 1
Coordinate 20,808,839     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 40
Allele Frequency
T:R0.42
C:V0.57
Amino Acid Change K->R (Lysine -> Arginine)
Sample ID IGL02869
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 96 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging

 Availability Details 
Availability Progeny Cryopreserved