Ndst3 - SNV Details



 Gene Information 
Gene Name Ndst3
Old Gene Names for Ndst3 4921531k01rik , 4930511p15rik
Gene Description N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 [Source:MGI Symbol;Acc:MGI:1932544]
MGI phenotype Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation.
Uniprot Name
CCDS Name
Gene GO
Golgi membrane; hydrolase activity; deacetylase activity; heparin biosynthetic process; [heparan sulfate]-glucosamine N-sulfotransferase activity; metabolic process; integral component of membrane; heparan sulfate proteoglycan biosynthetic process; sulfotransferase activity
Homolog in other species NDST3
Immgen Expression
LOW
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000027977
Chromosome 3
Coordinate 123,672,263     (Assembly: GRCm38)    
Ref Base G
Var Base T
Zygosity Heterozygous
Read Depth 13
Allele Frequency
G:R0.31
T:V0.69
Amino Acid Change T->N (Threonine -> Asparagine)
Sample ID IGL00543
Median Base Quality 40
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 26 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved