Zdhhc8 - SNV Details



 Gene Information 
Gene Name Zdhhc8
Old Gene Names for Zdhhc8 D16h22s1738e , E330009o14rik , Op53c05
Gene Description zinc finger, DHHC domain containing 8 [Source:MGI Symbol;Acc:MGI:1338012]
MGI phenotype Homozygous null females display impaired prepulse inhibition and reduced exploration in new environments. Homozygous null males display normal prepulse inhibition and only a slight decrease in exploration.
Uniprot Name
CCDS Name
Gene GO
mitochondrion; perinuclear region of cytoplasm; membrane; cytoplasmic vesicle membrane; receptor activity; zinc ion binding; metabolic process; protein binding; integral component of membrane; palmitoyltransferase activity; protein-cysteine S-palmitoyltransferase activity; locomotory behavior; protein palmitoylation; multicellular organismal development; Golgi apparatus
Homolog in other species ZDHHC8
Omim http://omim.org/entry/608784
Immgen Expression
MEDIAN(HIGHER IN PROB.FRBC.FL, PREB.FRD.FL, T.DPSM.TH, TGD.TH)
Gnf Expression
MEDIAN/HIGH(LOWER IN PANCREAS, KIDNEY, LIVER, BROWNFAT, SPLEEN, IMM.G2, THYROID, GI GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000060166
Chromosome 16
Coordinate 18,225,196     (Assembly: GRCm38)    
Ref Base A
Codon Change cTt/cCt
Var Base G
Zygosity Heterozygous
Read Depth 130
Allele Frequency
A:R0.53
G:V0.47
Amino Acid Position 380
Amino Acid Change L->P (Leucine -> Proline)
Sample ID IGL00338
Median Base Quality 38
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 29 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Sift Score 0.09
Sift Prediction tolerated

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved