Nmur2 - SNV Details



 Gene Information 
Gene Name Nmur2
Gene Description neuromedin U receptor 2 [Source:MGI Symbol;Acc:MGI:2441765]
MGI phenotype Mice homozygous for one knock-out allele exhibit increased chemical and thermal nociception thresholds, insensitivity to treatment with Nmu or Nms, and altered weight gain following a fast or when fed a high-fat diet that can be sex-dependent.
Uniprot Name
CCDS Name
Gene GO
activation of phospholipase A2 activity by calcium-mediated signaling; neuromedin U receptor activity; chloride transmembrane transport; inositol phosphate-mediated signaling; calcium ion transport; neuropeptide signaling pathway; positive regulation of cytosolic calcium ion concentration; integral component of membrane; chloride transport; neuromedin U binding; arachidonic acid secretion; G-protein coupled receptor activity; neuropeptide receptor activity; GTP binding; G-protein coupled receptor signaling pathway; plasma membrane; central nervous system development; phospholipase C-activating G-protein coupled receptor signaling pathway; intracellular calcium activated chloride channel activity; response to pain; grooming behavior; reduction of food intake in response to dietary excess
Homolog in other species NMUR2
Omim http://omim.org/entry/605108
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.DPSM.TH, T.8EFF.SP.OT1.D6.VSVOVA, T.8MEM.LN,TGD.SP,T.4FP3+25+.SP,T.4NVE.PP)
Gnf Expression
MEDIAN(HIGH IN UTERUS, OVARY)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000037393
Chromosome 11
Coordinate 56,040,777     (Assembly: GRCm38)    
Ref Base A
Var Base G
Zygosity Heterozygous
Read Depth 82
Allele Frequency
A:R0.50
G:V0.50
Amino Acid Change L->P (Leucine -> Proline)
Sample ID IGL00229
Median Base Quality 38.5
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 69 Other Mutations

 Predictions 
Polyphen Score 0.95
Polyphen Prediction Possibly damaging
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved