Tpp2 - SNV Details



 Gene Information 
Gene Name Tpp2
Gene Description tripeptidyl peptidase II [Source:MGI Symbol;Acc:MGI:102724]
MGI phenotype Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
Uniprot Name
CCDS Name
Gene GO
aminopeptidase activity; cytoplasm; peptide binding; nucleus; tripeptidyl-peptidase activity; proteolysis; serine-type endopeptidase activity
Homolog in other species TPP2
Omim http://omim.org/entry/190470
Immgen Expression
HIGH
Gnf Expression
HIGH
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000041763
Chromosome 1
Coordinate 43,983,291     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 56
Allele Frequency
T:R0.61
C:V0.39
Amino Acid Change F->L (Phenylalanine -> Leucine)
Sample ID IGL00977
Median Base Quality 41
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 22 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved , Line Propagating