Gpr125 - SNV Details



 Gene Information 
Gene Name Gpr125
Old Gene Names for Gpr125 Au044632 , 3830613o22rik
Gene Description G protein-coupled receptor 125 [Source:MGI Symbol;Acc:MGI:1917943]
MGI phenotype Homozygous mutant mice are fertile and grossly normal.
Uniprot Name
CCDS Name
Gene GO
G-protein coupled receptor activity
G-protein coupled receptor protein signaling pathway
biological_process
cell surface receptor linked signaling pathway
external side of plasma membrane
integral to membrane
membrane
molecular_function
neuropeptide signaling pathway
protein binding
transmembrane receptor activity
Homolog in other species GPR125
Omim http://omim.org/entry/612303
Immgen Expression
MEDIAN(HIGHER IN B.GC.SP, PROB.FRBC.FL, PREB.FRD.FL, DC8+.TH, T.8EFF.SP.OT1.D6.VSVOVA, TGD.TH, DC.LC.SK, MF.THIO5.II-480HI.PC, MO.6C+II-.LN)
Gnf Expression
MEDIAN(HIGH IN FERTILIZEDEGG, OOCYTE, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EMB GROUP, EPITH GROUP, SALIVARYGLAND, THYROID, PLACENTA, GI GROUP, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000029090
Chromosome 5
Coordinate 50,001,949     (Assembly: GRCm38)    
Ref Base C
Codon Change Ggg/Agg
Var Base T
Zygosity Heterozygous
Read Depth 80
Allele Frequency
C:0.57
T:0.41
Amino Acid Position 320
Amino Acid Change G->R (Glycine -> Arginine)
Sample ID IGL00848
Median Base Quality 37
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 53 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000030971:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Immunoglobulin I-set Ig_I-set IPR013098 ENSMUSP00000030971 Pfam 236
328 Description available Search pathways
Immunoglobulin subtype Ig_sub IPR003599 ENSMUSP00000030971 Smart 238
331 Description available Search pathways
GPCR, family 2, extracellular hormone receptor domain GPCR_2_extracellular_dom IPR001879 ENSMUSP00000030971 Prosite_profiles 312
407 Description available Search pathways
Immunoglobulin-like domain Ig-like_dom IPR007110 ENSMUSP00000030971 Prosite_profiles 231
329 Description available Search pathways

 Availability Details 
Availability Cryopreserved