Ago2 - SNV Details



 Gene Information 
Gene Name Ago2
Old Gene Names for Ago2 Eif2c2 , 1110029l17rik , 2310051f07rik , Ai225898 , Al022874 , Aw546247
Gene Description argonaute RISC catalytic subunit 2 [Source:MGI Symbol;Acc:MGI:2446632]
Uniprot Name
CCDS Name
Gene GO
cell differentiation; RISC complex; membrane; regulation of transcription
DNA-templated; mRNA binding; RNA binding; cytoplasm; metal ion binding; polysome; poly(A) RNA binding; gene silencing by RNA; mRNA cleavage; negative regulation of translational initiation; negative regulation of translation involved in gene silencing by miRNA; protein binding; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; cytoplasmic mRNA processing body; miRNA binding; pre-miRNA processing; nucleus; micro-ribonucleoprotein complex; post-embryonic development; RNA phosphodiester bond hydrolysis
endonucleolytic; ribonucleoprotein complex; siRNA binding; endoribonuclease activity
cleaving siRNA-paired mRNA; nucleic acid binding; mRNA cleavage involved in gene silencing by miRNA; endoribonuclease activity; positive regulation of nuclear-transcribed mRNA catabolic process
deadenylation-dependent decay; RNA 7-methylguanosine cap binding; transcription
DNA-templated; mRNA cap binding complex
Homolog in other species AGO2
Omim http://omim.org/entry/606229
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000036698
Chromosome 15
Coordinate 73,126,453     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 65
Allele Frequency
T:R0.37
C:V0.60
Amino Acid Change H->R (Histidine -> Arginine)
Sample ID IGL00163
Median Base Quality 35
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 50 Other Mutations

 Predictions 
Polyphen Score 0
Polyphen Prediction Benign

 Availability Details 
Availability Cryopreserved