Vrk3 - SNV Details



 Gene Information 
Gene Name Vrk3
Old Gene Names for Vrk3 Ai428238
Gene Description vaccinia related kinase 3 [Source:MGI Symbol;Acc:MGI:2182465]
Uniprot Name
CCDS Name
Gene GO
protein kinase activity; transferase activity
transferring phosphorus-containing groups; positive regulation of phosphoprotein phosphatase activity; nucleus; negative regulation of ERK1 and ERK2 cascade; protein phosphorylation; ATP binding; protein phosphatase binding
Homolog in other species VRK3
Immgen Expression
HIGH(LOWER IN DC.LC.SK)
Gnf Expression
MEDIAN(HIGH IN IMM.G1, IMM.G3)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000002205
Chromosome 7
Coordinate 44,753,820     (Assembly: GRCm38)    
Ref Base A
Var Base G
Zygosity Heterozygous
Read Depth 104
Allele Frequency
A:R0.50
G:V0.50
Amino Acid Change I->V (Isoleucine -> Valine)
Sample ID IGL02682
Median Base Quality 40
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 41 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved