Cdc45 - SNV Details



 Gene Information 
Gene Name Cdc45
Old Gene Names for Cdc45 Cdc45l
Gene Description cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]
MGI phenotype Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
Uniprot Name
CCDS Name
Gene GO
cell cycle; nucleus; DNA replication initiation; centrosome
Homolog in other species CDC45
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000000028
Chromosome 16
Coordinate 18,798,729     (Assembly: GRCm38)    
Ref Base C
Codon Change atG/atA
Var Base T
Zygosity Heterozygous
Read Depth 49
Allele Frequency
C:R0.55
T:V0.45
Amino Acid Position 200
Amino Acid Change M->I (Methionine -> Isoleucine)
Sample ID IGL02466
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 37 Other Mutations

 Predictions 
Polyphen Score 0.03
Polyphen Prediction Benign
Sift Score 0.26
Sift Prediction tolerated

 Protein domains 
ENSMUSP00000000028:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
CDC45 family CDC45 IPR003874 ENSMUSP00000000028 Pfam 18
563 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved