Cdc45 - SNV Details



 Gene Information 
Gene Name Cdc45
Old Gene Names for Cdc45 Cdc45l
Gene Description cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]
MGI phenotype Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
Uniprot Name
CCDS Name
Gene GO
cell cycle; nucleus; DNA replication initiation; centrosome
Homolog in other species CDC45
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000000028
Chromosome 16
Coordinate 18,798,729     (Assembly: GRCm38)    
Ref Base C
Var Base T
Zygosity Heterozygous
Read Depth 49
Allele Frequency
C:R0.55
T:V0.45
Amino Acid Change M->I (Methionine -> Isoleucine)
Sample ID IGL02466
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 37 Other Mutations

 Predictions 
Polyphen Score 0.03
Polyphen Prediction Benign

 Availability Details 
Availability