Il10rb,RP23-190G10.4 - SNV Details



 Gene Information 
Gene Name Il10rb , Rp23-190g10.4
Old Gene Names for Il10rb Ai528744 , D16h21s58 , D21s58h , Crfb4 , 6620401d04rik
Gene Description ,interleukin 10 receptor, beta [Source:MGI Symbol;Acc:MGI:109380]
MGI phenotype Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp.,NO_PHENOTYPE
Uniprot Name
CCDS Name
Gene GO
protein binding
protein binding; interleukin-10 receptor activity
Homolog in other species NO_HOMOLOG,IL10RB
Immgen Expression
MEDIAN(HIGH IN TGD.VG5+.ACT.IEL, NK GROUP, T.8EFF.SP.OT1.D6.VSVOVA, DC.LC.SK, MYELOID GROUP),NO_IMMGEN
Gnf Expression
LOW
LOW/MEDIAN(HIGH IN IMM GROUP, OSTEO GROUP)
HIGH(HIGHER IN IMM GROUPS, OESTEO GROUP, EPITH GROUP, BLADDER, UTERUS, OVARY, LUNG, TRACHEA AND ADIPOSETISSUE, PROSTATE, UMBLICALCORD),NO_GNF
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000022969
Chromosome 16
Coordinate 91,414,657     (Assembly: GRCm38)    
Ref Base T
Codon Change Tct/Gct
Var Base G
Zygosity Heterozygous
Read Depth 41
Allele Frequency
T:R0.54
G:V0.46
Amino Acid Position 128
Amino Acid Change S->A (Serine -> Alanine)
Sample ID IGL02392
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 42 Other Mutations

 Predictions 
Polyphen Score 0.6
Polyphen Prediction Possibly damaging
Sift Score 0.29
Sift Prediction tolerated

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved