Itga11 - SNV Details



 Gene Information 
Gene Name Itga11
Old Gene Names for Itga11 4732459h24rik
Gene Description integrin alpha 11 [Source:MGI Symbol;Acc:MGI:2442114]
MGI phenotype Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors.
Uniprot Name
CCDS Name
Gene GO
protein binding
Homolog in other species ITGA11
Omim http://omim.org/entry/604789
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.8MEM.LN, TGD.SPT.4NVE.PP, T.4FP3+25+.SP)
Gnf Expression
MEDIAN(HIGH IN RETINA, PITUITARY, DORSALROOTGANGLION, TRIGEMINAL, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EPITH GROUP, IMM.G2, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY, ADIPOSETISSUE, ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000032243
Chromosome 9
Coordinate 62,735,353     (Assembly: GRCm38)    
Ref Base T
Codon Change aTc/aAc
Var Base A
Zygosity Heterozygous
Read Depth 25
Allele Frequency
T:R0.44
A:V0.56
Amino Acid Position 186
Amino Acid Change I->N (Isoleucine -> Asparagine)
Sample ID IGL02451
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 50 Other Mutations

 Predictions 
Sift Score 0.23
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved