Trim25 - SNV Details



 Gene Information 
Gene Name Trim25
Old Gene Names for Trim25 Aa960166 , Al022677 , Zfp147
Gene Description tripartite motif-containing 25 [Source:MGI Symbol;Acc:MGI:102749]
MGI phenotype Engineered mutations result in a compromised response to estrogen resulting in functional but small uteri.
Uniprot Name
CCDS Name
Gene GO
cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding; cell junction; nucleus; innate immune response; defense response to virus
Homolog in other species TRIM25
Omim http://omim.org/entry/600453
Immgen Expression
HIGH(HIGHER IN MYELOID GROUP, DC GROUP, TGD GROUP)
Gnf Expression
MEDIAN/HIGH(HIGH IN RETINA, PITUITARY, DORSALROOTGANGLION, TRIGEMINAL, KIDNEY, LIVER, IMM.G1, IMM.G3, OSTEO GROUP, C2C12, UMBLICALCORD, NIH.3T3, EPITH GROUP, TRACHEA, LUNG, BLADDER, UTERUS, OVARY, ADIPOSETISSUE, ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000000275
Chromosome 11
Coordinate 88,999,804     (Assembly: GRCm38)    
Ref Base T
Codon Change Tgc/Cgc
Var Base C
Zygosity Heterozygous
Read Depth 28
Allele Frequency
T:R0.61
C:V0.39
Amino Acid Position 106
Amino Acid Change C->R (Cysteine -> Arginine)
Sample ID IGL02398
Median Base Quality 35
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 52 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved