Prlhr - SNV Details

 Gene Information 
Gene Name Prlhr
Old Gene Names for Prlhr Gpr10 , Gm339
Gene Description prolactin releasing hormone receptor [Source:MGI Symbol;Acc:MGI:2135956]
MGI phenotype Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.
Uniprot Name
Gene GO
feeding behavior; integral to membrane; hormone metabolic process; peptide hormone binding; neuropeptide Y receptor activity; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; plasma membrane
Homolog in other species PRLHR
Immgen Expression
Gnf Expression
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000045052
Chromosome 19
Coordinate 60,467,315     (Assembly: GRCm38)    
Ref Base G
Codon Change gCg/gAg
Var Base T
Zygosity Heterozygous
Read Depth 61
Allele Frequency
Amino Acid Position 271
Amino Acid Change A->E (Alanine -> Glutamic acid)
Sample ID IGL02398
Median Base Quality 35
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 52 Other Mutations

Polyphen Score 0.99
Polyphen Prediction Probably damaging
Sift Score 0.07
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Protein domains 
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
G protein-coupled receptor, rhodopsin-like GPCR_Rhodpsn IPR000276 ENSMUSP00000063114 Pfam 77
335 Description available Search pathways
7TM GPCR, olfactory receptor/chemoreceptor Srsx 7TM_GPCR_olfarory/Srsx IPR019424 ENSMUSP00000063114 Pfam 72
350 Description available Search pathways
Prolactin-releasing peptide receptor Prolrel_pep_rcpt IPR001402 ENSMUSP00000063114 Prints 256
278 Description available Search pathways
GPCR, rhodopsin-like, 7TM GPCR_Rhodpsn_7TM IPR017452 ENSMUSP00000063114 Prosite_profiles 77
335 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved