Prlhr - SNV Details



 Gene Information 
Gene Name Prlhr
Old Gene Names for Prlhr Gpr10 , Gm339
Gene Description prolactin releasing hormone receptor [Source:MGI Symbol;Acc:MGI:2135956]
MGI phenotype Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.
Uniprot Name
CCDS Name
Gene GO
feeding behavior; integral to membrane; hormone metabolic process; peptide hormone binding; neuropeptide Y receptor activity; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway; plasma membrane
Homolog in other species PRLHR
Immgen Expression
LOW
Gnf Expression
LOW
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000045052
Chromosome 19
Coordinate 60,467,315     (Assembly: GRCm38)    
Ref Base G
Codon Change gCg/gAg
Var Base T
Zygosity Heterozygous
Read Depth 61
Allele Frequency
G:R0.59
T:V0.41
Amino Acid Position 271
Amino Acid Change A->E (Alanine -> Glutamic acid)
Sample ID IGL02398
Median Base Quality 35
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 52 Other Mutations

 Predictions 
Polyphen Score 0.99
Polyphen Prediction Probably damaging
Sift Score 0.07
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved