Ncoa3 - SNV Details

 Gene Information 
Gene Name Ncoa3
Old Gene Names for Ncoa3 2010305b15rik , Aw321064
Gene Description nuclear receptor coactivator 3 [Source:MGI Symbol;Acc:MGI:1276535]
MGI phenotype Mice homozygous for a knock-out allele exhibit reduced body weight. Mice homozygous for a targeted allele affecting phosphorylation sites exhibit increased body weight, increased adiposity, hypoactivity, abnormal glucose homeostasis, and increased susceptibility to chemically induced tumors.
Uniprot Name
Gene GO
transcription coactivator activity; nuclear hormone receptor binding; histone acetylation; positive regulation of sequence-specific DNA binding transcription factor activity; chromatin binding; positive regulation of intracellular estrogen receptor signaling pathway; histone acetyltransferase activity; transcription
DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; mammary gland branching involved in thelarche; cytoplasm; signal transduction; regulation of RNA biosynthetic process; positive regulation of keratinocyte differentiation; protein binding; vagina development; nucleus; multicellular organism growth; estrogen receptor binding; protein dimerization activity; regulation of transcription
DNA-dependent; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; signal transducer activity; protein N-terminus binding; positive regulation of gene expression; Golgi apparatus; developmental growth
Homolog in other species NCOA3
Immgen Expression
Gnf Expression
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000027678
Chromosome 2
Coordinate 166,052,817     (Assembly: GRCm38)    
Ref Base T
Codon Change gTg/gAg
Var Base A
Zygosity Heterozygous
Read Depth 132
Allele Frequency
Amino Acid Position 340
Amino Acid Change V->E (Valine -> Glutamic acid)
Sample ID IGL02381
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 38 Other Mutations

Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious

 Protein domains 
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Nuclear receptor coactivator Nuclear_rcpt_coactivator IPR017426 ENSMUSP00000085416 PIRSF 1
1403 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved