Irf9 - SNV Details



 Gene Information 
Gene Name Irf9
Old Gene Names for Irf9 Isgf3g
Gene Description interferon regulatory factor 9 [Source:MGI Symbol;Acc:MGI:107587]
MGI phenotype Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, antivirus response induced by Ifn alfpha and Ifn gamma are impaired.
Uniprot Name
CCDS Name
Gene GO
transcription
DNA-dependent; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; type I interferon biosynthetic process; regulation of transcription
DNA-dependent; regulatory region DNA binding
Homolog in other species IRF9
Immgen Expression
MEDIAN(LOW IN PROB.FRBC.FL, DC8+.TH, DC.LC.SK)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000002325
Chromosome 14
Coordinate 55,607,739     (Assembly: GRCm38)    
Ref Base G
Codon Change cGc/cAc
Var Base A
Zygosity Heterozygous
Read Depth 32
Allele Frequency
G:R0.56
A:V0.44
Amino Acid Position 352
Amino Acid Change R->H (Arginine -> Histidine)
Sample ID IGL02283
Median Base Quality 35
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 27 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000120525:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
SMAD/FHA domain SMAD_FHA_domain IPR008984 ENSMUSP00000120525 Superfamily 263
459 Description available Search pathways
Interferon regulatory factor-3 Interferon_reg_factor-3 IPR019471 ENSMUSP00000120525 Pfam 278
441 Description available Search pathways

 Availability Details 
Availability Cryopreserved