Gpr125 - SNV Details



 Gene Information 
Gene Name Gpr125
Old Gene Names for Gpr125 Au044632 , 3830613o22rik
Gene Description G protein-coupled receptor 125 [Source:MGI Symbol;Acc:MGI:1917943]
MGI phenotype Homozygous mutant mice are fertile and grossly normal.
Uniprot Name
CCDS Name
Gene GO
membrane; integral to membrane; transmembrane signaling receptor activity; neuropeptide signaling pathway; external side of plasma membrane; protein binding; G-protein coupled receptor activity; cell surface receptor signaling pathway; G-protein coupled receptor signaling pathway; biological_process
Homolog in other species GPR125
Omim http://omim.org/entry/612303
Immgen Expression
MEDIAN(HIGHER IN B.GC.SP, PROB.FRBC.FL, PREB.FRD.FL, DC8+.TH, T.8EFF.SP.OT1.D6.VSVOVA, TGD.TH, DC.LC.SK, MF.THIO5.II-480HI.PC, MO.6C+II-.LN)
Gnf Expression
MEDIAN(HIGH IN FERTILIZEDEGG, OOCYTE, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EMB GROUP, EPITH GROUP, SALIVARYGLAND, THYROID, PLACENTA, GI GROUP, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000029090
Chromosome 5
Coordinate 50,058,558     (Assembly: GRCm38)    
Ref Base A
Codon Change gTc/gCc
Var Base G
Zygosity Heterozygous
Read Depth 32
Allele Frequency
A:R0.53
G:V0.47
Amino Acid Position 73
Amino Acid Change V->A (Valine -> Alanine)
Sample ID IGL02351
Median Base Quality 35
Backgrounds C57BL/6j
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 57 Other Mutations

 Predictions 
Polyphen Score 0.11
Polyphen Prediction Benign
Sift Score 0.04
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Line Propagating