Mst1r - SNV Details



 Gene Information 
Gene Name Mst1r
Old Gene Names for Mst1r Ron
Gene Description macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Source:MGI Symbol;Acc:MGI:99614]
MGI phenotype This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus.
Uniprot Name
CCDS Name
Gene GO
enzyme binding; protein kinase activity; membrane; integral to membrane; receptor activity; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; response to virus; transferase activity
transferring phosphorus-containing groups; virus-host interaction; protein binding; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; innate immune response; protein tyrosine kinase activity; ATP binding; stress fiber; plasma membrane; transmembrane receptor protein tyrosine kinase activity; multicellular organismal development
Homolog in other species MST1R
Omim http://omim.org/entry/600168
Immgen Expression
MEDIAN(HIGH IN TGD.VG5+.ACT.IEL, NK GROUP, T.8EFF.SP.OT1.D6.VSVOVA, DC.LC.SK, MYELOID GROUP)
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000032584
Chromosome 9
Coordinate 107,907,869     (Assembly: GRCm38)    
Ref Base A
Codon Change tAt/tGt
Var Base G
Zygosity Heterozygous
Read Depth 61
Allele Frequency
A:R0.54
G:V0.46
Amino Acid Position 242
Amino Acid Change Y->C (Tyrosine -> Cysteine)
Sample ID IGL02203
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 40 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0.03
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000035203:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Sema domain Semaphorin/CD100_Ag IPR001627 ENSMUSP00000035203 Superfamily 45
524 Description available Search pathways
Sema domain Semaphorin/CD100_Ag IPR001627 ENSMUSP00000035203 Smart 57
510 Description available Search pathways
Sema domain Semaphorin/CD100_Ag IPR001627 ENSMUSP00000035203 Pfam 65
506 Description available Search pathways
Tyrosine-protein kinase, HGF/MSP receptor Tyr_kinase_HGF/MSP_rcpt IPR016244 ENSMUSP00000035203 PIRSF 3
1378 Description available Search pathways
Sema domain Semaphorin/CD100_Ag IPR001627 ENSMUSP00000035203 Prosite_profiles 33
524 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved