Ppp2r4 - SNV Details



 Gene Information 
Gene Name Ppp2r4
Old Gene Names for Ppp2r4 C77440 , 2610042b21rik , N28142
Gene Description protein phosphatase 2A, regulatory subunit B (PR 53) [Source:MGI Symbol;Acc:MGI:1346006]
Uniprot Name
CCDS Name
Gene GO
ATPase activity; protein phosphatase type 2A regulator activity; positive regulation of protein dephosphorylation; cytoplasm; positive regulation of apoptotic process; protein homodimerization activity; positive regulation of phosphoprotein phosphatase activity; negative regulation of protein dephosphorylation; negative regulation of phosphoprotein phosphatase activity; phosphatase activator activity; nucleus; protein tyrosine phosphatase activator activity; protein folding; ATP binding; receptor binding; protein phosphatase 2A binding; peptidyl-prolyl cis-trans isomerase activity; calcium channel complex; regulation of phosphoprotein phosphatase activity; ATP catabolic process
Homolog in other species PPP2R4
Omim http://omim.org/entry/600756
Immgen Expression
HIGH(HIGHER IN BCELL GROUP, DC GROUP, ABT GROUP, MO.6C+II-.LN)
Gnf Expression
HIGH(LOWER IN FERTILIZED EGG, OOCYTE, PANCREAS, SPLEEN, BONE MARROW, THYROID)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000039515
Chromosome 2
Coordinate 30,443,296     (Assembly: GRCm38)    
Ref Base A
Codon Change Act/Gct
Var Base G
Zygosity Heterozygous
Read Depth 39
Allele Frequency
A:R0.56
G:V0.41
Amino Acid Position 265
Amino Acid Change T->A (Threonine -> Alanine)
Sample ID IGL02066
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 60 Other Mutations

 Predictions 
Polyphen Score 0.17
Polyphen Prediction Benign
Sift Score 0.01
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000046837:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Phosphotyrosyl phosphatase activator, PTPA Phstyr_phstse_ac IPR004327 ENSMUSP00000046837 PIRSF 4
322 Description available Search pathways
Phosphotyrosyl phosphatase activator, PTPA Phstyr_phstse_ac IPR004327 ENSMUSP00000046837 Pfam 26
319 Description available Search pathways

 Availability Details 
Availability Cryopreserved