Cry2 - SNV Details



 Gene Information 
Gene Name Cry2
Old Gene Names for Cry2 Av006279 , D130054k12rik
Gene Description cryptochrome 2 (photolyase-like) [Source:MGI Symbol;Acc:MGI:1270859]
MGI phenotype Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
Uniprot Name
CCDS Name
Gene GO
nucleoplasm; mitochondrion; transcription
DNA-dependent; photoreceptor activity; cytoplasm; DNA repair; protein binding transcription factor activity; protein import into nucleus; DNA binding; protein binding; damaged DNA binding; nucleus; cytosol; DNA photolyase activity; regulation of sodium-dependent phosphate transport; nucleotide binding; extracellular region; negative regulation of transcription from RNA polymerase II promoter; circadian rhythm; protein-chromophore linkage; regulation of circadian rhythm; single-stranded DNA binding
Homolog in other species CRY2
Omim http://omim.org/entry/603732
Immgen Expression
MEDIAN(LOWER IN MYELOID GROUP AND DC.LC.SK)
Gnf Expression
HIGH
HIGH(HIGHER IN IMM GROUP, NS GROUPS)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000068742
Chromosome 2
Coordinate 92,433,821     (Assembly: GRCm38)    
Ref Base T
Codon Change aAc/aGc
Var Base C
Zygosity Heterozygous
Read Depth 21
Allele Frequency
T:R0.62
C:V0.38
Amino Acid Position 68
Amino Acid Change N->S (Asparagine -> Serine)
Sample ID IGL02167
Median Base Quality 38
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 48 Other Mutations

 Predictions 
Polyphen Score 0.14
Polyphen Prediction Benign
Sift Score 0.03
Sift Prediction deleterious

 Availability Details 
Availability Progeny Cryopreserved