Fndc3b - SNV Details



 Gene Information 
Gene Name Fndc3b
Old Gene Names for Fndc3b 1600019o04rik , Aw550168
Gene Description fibronectin type III domain containing 3B [Source:MGI Symbol;Acc:MGI:1919257]
MGI phenotype Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.
Uniprot Name
CCDS Name
Gene GO
integral to membrane; endoplasmic reticulum; protein binding; positive regulation of fat cell differentiation; molecular_function
Homolog in other species FNDC3B
Omim http://omim.org/entry/611909
Immgen Expression
MEDIAN(HIGH IN DC GROUP, MYELOID GROUP, BCELL GROUP)
Gnf Expression
MEDIAN(HIGH IN RETINA, PITUITARY, DORSALROOTGANGLION, TRIGEMINAL, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EPITH GROUP, IMM.G2, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY, ADIPOSETISSUE, ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000039286
Chromosome 3
Coordinate 27,538,117     (Assembly: GRCm38)    
Ref Base A
Codon Change Tcc/Ccc
Var Base G
Zygosity Heterozygous
Read Depth 43
Allele Frequency
A:R0.44
G:V0.56
Amino Acid Position 211
Amino Acid Change S->P (Serine -> Proline)
Sample ID IGL02154
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 33 Other Mutations

 Predictions 
Polyphen Score 0.09
Polyphen Prediction Benign
Sift Score 0.19
Sift Prediction tolerated

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved