Qpct - SNV Details



 Gene Information 
Gene Name Qpct
Old Gene Names for Qpct 5730422a13rik
Gene Description glutaminyl-peptide cyclotransferase (glutaminyl cyclase) [Source:MGI Symbol;Acc:MGI:1917786]
MGI phenotype Mice exhibit normal motor coordination and spatial working memory.
Uniprot Name
CCDS Name
Gene GO
zinc ion binding; peptidase activity; peptidyl-pyroglutamic acid biosynthetic process
using glutaminyl-peptide cyclotransferase; extracellular region; proteolysis; glutaminyl-peptide cyclotransferase activity
Homolog in other species QPCT
Omim http://omim.org/entry/607065
Immgen Expression
MEDIAN(HIGH IN TGD.VG5+.ACT.IEL, NK GROUP, T.8EFF.SP.OT1.D6.VSVOVA, DC.LC.SK, MYELOID GROUP)
Gnf Expression
HIGH(LOWER IN TESTIS, FERTILIZEDEGG, OOCYTE, LIVER, EMB GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000024084
Chromosome 17
Coordinate 79,070,716     (Assembly: GRCm38)    
Ref Base T
Codon Change gTg/gCg
Var Base C
Zygosity Heterozygous
Read Depth 49
Allele Frequency
T:R0.57
C:V0.43
Amino Acid Position 105
Amino Acid Change V->A (Valine -> Alanine)
Sample ID IGL02147
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 37 Other Mutations

 Predictions 
Polyphen Score 0.48
Polyphen Prediction Possibly damaging
Sift Score 0
Sift Prediction deleterious
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved