Fat4 - SNV Details



 Gene Information 
Gene Name Fat4
Old Gene Names for Fat4 6030410k14rik
Gene Description FAT tumor suppressor homolog 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:3045256]
Uniprot Name
CCDS Name
Gene GO
membrane; integral to membrane; homophilic cell adhesion; protein binding; plasma membrane; calcium ion binding
Homolog in other species FAT4
Omim http://omim.org/entry/612411
Immgen Expression
MEDIAN(LOWER IN DC8+.TH, TGD.VG5+.ACT.IEL)
Gnf Expression
LOW
MEDIAN(HIGH IN RETINA, PITUITARY, DORSALROOTGANGLION, TRIGEMINAL, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EPITH GROUP, IMM.G2, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY, ADIPOSETISSUE, ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000046743
Chromosome 3
Coordinate 38,889,199     (Assembly: GRCm38)    
Ref Base C
Codon Change aCa/aAa
Var Base A
Zygosity Heterozygous
Read Depth 19
Allele Frequency
C:R0.37
A:V0.63
Amino Acid Position 747
Amino Acid Change T->K (Threonine -> Lysine)
Sample ID IGL02103
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 52 Other Mutations

 Predictions 
Polyphen Score 0.58
Polyphen Prediction Possibly damaging
Sift Score 0.29
Sift Prediction tolerated

 Protein domains 
ENSMUSP00000061836:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Cadherin Cadherin IPR002126 ENSMUSP00000061836 Prosite_profiles 690
793 Description available Search pathways
Cadherin Cadherin IPR002126 ENSMUSP00000061836 Pfam 694
784 Description available Search pathways
Cadherin-like Cadherin-like IPR015919 ENSMUSP00000061836 Superfamily 682
785 Description available Search pathways

 Availability Details 
Availability Progeny Cryopreserved