Pla2g4a - SNV Details



 Gene Information 
Gene Name Pla2g4a
Old Gene Names for Pla2g4a Pla2g4
Gene Description phospholipase A2, group IVA (cytosolic, calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256]
MGI phenotype Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.
Uniprot Name
CCDS Name
Gene GO
response to lipopolysaccharide; positive regulation of prostaglandin biosynthetic process; response to methylmercury; perinuclear region of cytoplasm; phospholipase A2 activity; ovulation from ovarian follicle; calcium-dependent phospholipid binding; positive regulation of apoptotic process; icosanoid biosynthetic process; zymogen granule; positive regulation of vesicle fusion; endoplasmic reticulum; luteolysis; arachidonic acid metabolic process; lysophospholipase activity; response to organic nitrogen; metabolic process; response to glucocorticoid stimulus; protein binding; surfactant homeostasis; response to vitamin D; nucleus; arachidonic acid secretion; regulation of cell proliferation; cytosol; aging; cellular response to antibiotic; calcium-dependent phospholipase A2 activity; decidualization; positive regulation of fever generation; phospholipid catabolic process; response to calcium ion; response to hydrogen peroxide; calcium ion binding; positive regulation of bone mineralization; positive regulation of cell proliferation; phospholipase activity; Golgi apparatus; response to heat
Homolog in other species PLA2G4A
Omim http://omim.org/entry/600522
Immgen Expression
LOW(HIGH IN MYELOID GROUP, DC GROUP, TGD.SP)
Gnf Expression
MEDIAN(HIGH IN FERTILIZEDEGG, OOCYTE, IMM.G3, OSTEO GROUP, C2C12, UMBLICALCORD, NIH.3T3)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000056220
Chromosome 1
Coordinate 149,901,199     (Assembly: GRCm38)    
Ref Base A
Codon Change gaT/gaA
Var Base T
Zygosity Heterozygous
Read Depth 80
Allele Frequency
A:R0.52
T:V0.46
Amino Acid Position 55
Amino Acid Change D->E (Aspartic acid -> Glutamic acid)
Sample ID IGL02103
Median Base Quality 38.5
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 52 Other Mutations

 Predictions 
Polyphen Score 0.96
Polyphen Prediction Probably damaging
Sift Score 0.2
Sift Prediction tolerated

 Availability Details 
Availability Progeny Cryopreserved