Trpm2 - SNV Details



 Gene Information 
Gene Name Trpm2
Old Gene Names for Trpm2 9830168k16rik , C79133 , Trrp7
Gene Description transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901]
MGI phenotype Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.
Uniprot Name
CCDS Name
Gene GO
manganese ion transmembrane transport; membrane; response to hydroperoxide; integral to membrane; hydrolase activity; sodium channel activity; ADP-ribose diphosphatase activity; ion channel activity; ion transport; transmembrane transport; manganese ion transmembrane transporter activity; plasma membrane; calcium channel activity; manganese ion transport
Homolog in other species TRPM2
Omim http://omim.org/entry/603749
Immgen Expression
LOW/MEDIAN(HIGH IN MF.RP.SP)
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000009292
Chromosome 10
Coordinate 77,942,996     (Assembly: GRCm38)    
Ref Base G
Var Base A
Zygosity Heterozygous
Read Depth 31
Allele Frequency
G:R0.48
A:V0.52
Amino Acid Change Q->Stop (Glutamine -> Stop)
Sample ID IGL02094
Median Base Quality 39
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 35 Other Mutations

 Predictions 
Polyphen Prediction N/A
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved