Ksr1 - SNV Details



 Gene Information 
Gene Name Ksr1
Gene Description kinase suppressor of ras 1 [Source:MGI Symbol;Acc:MGI:105051]
MGI phenotype Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.
Uniprot Name
CCDS Name
Gene GO
intracellular signal transduction; protein kinase activity; mitogen-activated protein kinase kinase binding; kinase activity; metal ion binding; endoplasmic reticulum membrane; intracellular; positive regulation of MAPK cascade; transferase activity
transferring phosphorus-containing groups; protein binding; MAP-kinase scaffold activity; protein phosphorylation; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity
Homolog in other species KSR1
Omim http://omim.org/entry/601132
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.8MEM.LN, TGD.SPT.4NVE.PP, T.4FP3+25+.SP)
Gnf Expression
LOW/MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000018334
Chromosome 11
Coordinate 79,021,450     (Assembly: GRCm38)    
Ref Base T
Codon Change aAc/aGc
Var Base C
Zygosity Heterozygous
Read Depth 71
Allele Frequency
T:R0.44
C:V0.56
Amino Acid Position 693
Amino Acid Change N->S (Asparagine -> Serine)
Sample ID IGL02025
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 34 Other Mutations

 Predictions 
Polyphen Score 0.09
Polyphen Prediction Benign
Sift Score 0.13
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved