Map4k3 - SNV Details



 Gene Information 
Gene Name Map4k3
Old Gene Names for Map4k3 4833416m01rik , 9530052p13rik
Gene Description mitogen-activated protein kinase kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:2154405]
Uniprot Name
CCDS Name
Gene GO
protein kinase activity; intracellular protein kinase cascade; transferase activity
transferring phosphorus-containing groups; protein binding; protein phosphorylation; small GTPase regulator activity; response to stress; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity
Homolog in other species MAP4K3
Immgen Expression
MEDIAN(LOW IN GN.BM)
Gnf Expression
LOW/MEDIAN
MEDIAN/HIGH(LOWER IN TESTIS, FERTILIZEDEGG, OOCYTE, KIDNEY, LIVER, SPLEEN, THYROID)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000024242
Chromosome 17
Coordinate 80,609,826     (Assembly: GRCm38)    
Ref Base A
Codon Change Tac/Cac
Var Base G
Zygosity Heterozygous
Read Depth 22
Allele Frequency
A:R0.50
G:V0.50
Amino Acid Position 574
Amino Acid Change Y->H (Tyrosine -> Histidine)
Sample ID IGL02021
Median Base Quality 39.5
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 40 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0.75
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved , Progeny Cryopreserved