Fmnl3 - SNV Details



 Gene Information 
Gene Name Fmnl3
Old Gene Names for Fmnl3 2700073b04rik , Wbp3
Gene Description formin-like 3 [Source:MGI Symbol;Acc:MGI:109569]
Uniprot Name
CCDS Name
Gene GO
Rho GTPase binding
actin binding
actin cytoskeleton organization
binding
biological_process
cellular component organization
cellular_component
protein binding
Homolog in other species FMNL3
Immgen Expression
MEDIAN(HIGH IN GN.BM, B.FO.SP, B.MZ.SP, B1A.PC, NK GROUP, ABT GROUP, TACTIVATION GROUP)
Gnf Expression
MEDIAN(HIGH IN FERTILIZEDEGG, OOCYTE, IMM.G3, OSTEO GROUP, C2C12, UMBLICALCORD, NIH.3T3)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000023008
Chromosome 15
Coordinate 99,322,670     (Assembly: GRCm38)    
Ref Base G
Codon Change aCa/aTa
Var Base A
Zygosity Heterozygous
Read Depth 23
Allele Frequency
G:0.61
A:0.39
Amino Acid Position 577
Amino Acid Change T->I (Threonine -> Isoleucine)
Sample ID IGL00648
Median Base Quality 39
Backgrounds C57BL/6n
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 13 Other Mutations

 Predictions 
Polyphen Score 0.4
Polyphen Prediction Benign
Sift Score 0.4
Sift Prediction tolerated

 Protein domains 
ENSMUSP00000085566:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Actin-bd_FH2/DRF_autoreg IPR003104 ENSMUSP00000085566 Smart 561
995
Formin, FH2 domain FH2_actin-bd IPR015425 ENSMUSP00000085566 Pfam 562
926 Description available Search pathways
Formin, FH2 domain FH2_actin-bd IPR015425 ENSMUSP00000085566 Superfamily 527
945 Description available Search pathways

 Availability Details 
Availability Cryopreserved