Bcl6b - SNV Details



 Gene Information 
Gene Name Bcl6b
Old Gene Names for Bcl6b Bazf
Gene Description B cell CLL/lymphoma 6, member B [Source:MGI Symbol;Acc:MGI:1278332]
MGI phenotype Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells.
Uniprot Name
CCDS Name
Gene GO
intracellular; zinc ion binding; DNA binding; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter
Homolog in other species BCL6B
Omim http://omim.org/entry/608992
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.8MEM.LN, TGD.SPT.4NVE.PP, T.4FP3+25+.SP)
Gnf Expression
MEDIAN
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000000317
Chromosome 11
Coordinate 70,226,743     (Assembly: GRCm38)    
Ref Base T
Codon Change tAc/tTc
Var Base A
Zygosity Heterozygous
Read Depth 40
Allele Frequency
T:R0.38
A:V0.62
Amino Acid Position 379
Amino Acid Change Y->F (Tyrosine -> Phenylalanine)
Sample ID IGL01942
Median Base Quality 34
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 39 Other Mutations

 Predictions 
Polyphen Score 0.98
Polyphen Prediction Probably damaging
Sift Score 0.02
Sift Prediction deleterious

 Availability Details 
Availability Cryopreserved