Kalrn - SNV Details



 Gene Information 
Gene Name Kalrn
Old Gene Names for Kalrn 2210407g14rik , Hapip , Av235988 , E530005c20rik , Gm539
Gene Description kalirin, RhoGEF kinase [Source:MGI Symbol;Acc:MGI:2685385]
Uniprot Name
CCDS Name
Gene GO
intracellular signal transduction; protein kinase activity; perinuclear region of cytoplasm; kinase activity; metal ion binding; axonogenesis; intracellular; transferase activity
transferring phosphorus-containing groups; Rho guanyl-nucleotide exchange factor activity; protein binding; neuronal cell body; cytoskeleton; regulation of Rho protein signal transduction; protein phosphorylation; regulation of dendrite development; protein tyrosine kinase activity; ATP binding; neuron projection; phospholipid binding; protein serine/threonine kinase activity
Homolog in other species KALRN
Omim http://omim.org/entry/604605
Immgen Expression
MEDIAN(HIGHER IN NK GROUP, T.DPSM.TH, T.8EFF.SP.OT1.D6.VSVOVA, T.8MEM.LN,TGD.SP,T.4FP3+25+.SP,T.4NVE.PP)
Gnf Expression
LOW/MEDIAN(HIGH IN FERTILIZEDEGG, OOCYTE)
Novel Yes

 Mutation Information 
Mutation Type Splice
Ensembl ID ENSMUSG00000061751
Chromosome 16
Coordinate 34,198,512     (Assembly: GRCm38)    
Ref Base A
Var Base T
Zygosity Heterozygous
Read Depth 15
Allele Frequency
A:R0.53
T:V0.47
Amino Acid Change Disrupted splicing
Splice Position 10
Sample ID IGL01934
Median Base Quality 37
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 59 Other Mutations

 Predictions 
Druggable Yes, View known drug interactions

 Availability Details 
Availability Cryopreserved