Penk-rs - SNV Details



 Gene Information 
Gene Name Penk-rs
Old Gene Names for Penk-rs Penk1 , Ai326464 , Penk , Penk2
Gene Description preproenkephalin [Source:MGI Symbol;Acc:MGI:104629]
MGI phenotype Mice homozygous for one knock-out allele retain physical dependence but do not develop analgesic tolerance to morphine. Ovariectomized females homozygous for another knock-out allele exhibit exaggerated responses in fear and anxiety paradigms but retain normal sucrose intake and lordosis behavior.
Uniprot Name
CCDS Name
Gene GO
sensory perception of pain; behavioral fear response; opioid peptide activity; neuropeptide signaling pathway; extracellular region; behavior
Homolog in other species PENK
Omim http://omim.org/entry/131330
Immgen Expression
MEDIAN(HIGH IN TGD GROUP, ABT GROUP, TACTIVATION GROUP)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000045573
Chromosome 4
Coordinate 4,134,465     (Assembly: GRCm38)    
Ref Base T
Codon Change Atc/Gtc
Var Base C
Zygosity Heterozygous
Read Depth 31
Allele Frequency
T:R0.55
C:V0.45
Amino Acid Position 61
Amino Acid Change I->V (Isoleucine -> Valine)
Sample ID IGL01901
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 41 Other Mutations

 Predictions 
Polyphen Score 0.01
Polyphen Prediction Benign
Sift Score 0.6
Sift Prediction tolerated

 Availability Details 
Availability Cryopreserved