Zfp110 - SNV Details



 Gene Information 
Gene Name Zfp110
Old Gene Names for Zfp110 2900024e01rik , N28112
Gene Description zinc finger protein 110 [Source:MGI Symbol;Acc:MGI:1890378]
MGI phenotype Homozygous mutants on a C57BL/6 background die at embryonic day 12. On a strain 129 background, mutants are viable and fertile, but males are more docile and testis weight is greatly reduced. On an F2 background, 20% of homozygous pups die neonatally.
Uniprot Name
CCDS Name
Gene GO
sequence-specific DNA binding; transcription
DNA-dependent; apoptotic process; cytoplasm; regulation of JNK cascade; intracellular; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding; neuron apoptotic process; nucleus; cytosol; regulation of transcription
DNA-dependent; nucleic acid binding; viral reproduction; neurotrophin p75 receptor binding
Homolog in other species ZNF274
Immgen Expression
MEDIAN(LOW IN PROB.FRBC.FL, DC8+.TH, DC.LC.SK)
Gnf Expression
MEDIAN(HIGHER IN TESTIS)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000058638
Chromosome 7
Coordinate 12,849,540     (Assembly: GRCm38)    
Ref Base T
Codon Change gTc/gCc
Var Base C
Zygosity Heterozygous
Read Depth 39
Allele Frequency
T:R0.59
C:V0.41
Amino Acid Position 705
Amino Acid Change V->A (Valine -> Alanine)
Sample ID IGL01859
Median Base Quality 38
Backgrounds Balb/c:C57BL/6
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 46 Other Mutations

 Predictions 
Polyphen Score 0.12
Polyphen Prediction Benign
Sift Score 0.09
Sift Prediction tolerated

 Protein domains 
ENSMUSP00000004614:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Zinc finger, C2H2-like Znf_C2H2-like IPR015880 ENSMUSP00000004614 Smart 688
710 Description available Search pathways
Zinc finger, C2H2 Znf_C2H2 IPR007087 ENSMUSP00000004614 Prosite_profiles 688
715 Description available Search pathways

 Availability Details 
Availability Cryopreserved