Arhgap32 - SNV Details



 Gene Information 
Gene Name Arhgap32
Old Gene Names for Arhgap32 3426406o18rik , Grit
Gene Description Rho GTPase activating protein 32 [Source:MGI Symbol;Acc:MGI:2450166]
MGI phenotype Mice homozygous for a null mutation are fertile but display abnormal neurite growth.
Uniprot Name
CCDS Name
Gene GO
endosome membrane; postsynaptic membrane; Golgi membrane; cell cortex; signal transduction; positive regulation of GTPase activity; cell communication; endoplasmic reticulum membrane; intracellular; Rho protein signal transduction; protein binding; GTPase activator activity; cell junction; phosphatidylinositol binding; actin cytoskeleton; plasma membrane; postsynaptic density
Homolog in other species ARHGAP32
Omim http://omim.org/entry/608541
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000041444
Chromosome 9
Coordinate 32,247,190     (Assembly: GRCm38)    
Ref Base A
Codon Change Att/Gtt
Var Base G
Zygosity Heterozygous
Read Depth 55
Allele Frequency
A:R0.55
G:V0.46
Amino Acid Position 523
Amino Acid Change I->V (Isoleucine -> Valine)
Sample ID IGL01791
Median Base Quality 41
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 39 Other Mutations

 Predictions 
Polyphen Score 0.09
Polyphen Prediction Benign
Sift Score 0.01
Sift Prediction deleterious

 Protein domains 
ENSMUSP00000133898:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Rho GTPase-activating protein domain RhoGAP_dom IPR000198 ENSMUSP00000133898 Smart 383
564 Description available Search pathways
Rho GTPase-activating protein domain RhoGAP_dom IPR000198 ENSMUSP00000133898 Pfam 386
534 Description available Search pathways
Rho GTPase activation protein Rho_GTPase_activation_prot IPR008936 ENSMUSP00000133898 Superfamily 368
567 Description available Search pathways
Rho GTPase-activating protein domain RhoGAP_dom IPR000198 ENSMUSP00000133898 Prosite_profiles 372
567 Description available Search pathways

 Availability Details 
Availability Cryopreserved