Ago3 - SNV Details



 Gene Information 
Gene Name Ago3
Old Gene Names for Ago3 C130014l07rik , Eif2c3 , Aw048688
Gene Description eukaryotic translation initiation factor 2C, 3 [Source:MGI Symbol;Acc:MGI:2446634]
Uniprot Name
CCDS Name
Gene GO
mRNA catabolic process; RNA binding; negative regulation of translation involved in gene silencing by miRNA; protein binding; cytoplasmic mRNA processing body; micro-ribonucleoprotein complex; nucleic acid binding; translation initiation factor activity
Homolog in other species EIF2C3
Omim http://omim.org/entry/607355
Immgen Expression
MEDIAN(LOW IN GN.BM)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000028842
Chromosome 4
Coordinate 126,403,282     (Assembly: GRCm38)    
Ref Base A
Codon Change Tcc/Ccc
Var Base G
Zygosity Heterozygous
Read Depth 10
Allele Frequency
A:R0.60
G:V0.40
Amino Acid Position 181
Amino Acid Change S->P (Serine -> Proline)
Sample ID IGL01826
Median Base Quality 40
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 20 Other Mutations

 Predictions 
Polyphen Score 1
Polyphen Prediction Probably damaging
Sift Score 0
Sift Prediction deleterious

 Availability Details 
Availability Cryopreserved